5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

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Chemical Name:5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide
CAS No.:1374672-74-8
Molecular Formula:C₂₀H₂₁FN₆O₃
Molecular Weight:412.424
Hs Code.:

Synonyms:5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

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Chemical Property of 5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

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Technology Process of 5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

There total 8 articles about 5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 38041-19-9
4-aminotetrahydropyran

: 1374673-31-0
5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid

: 1374672-74-8
5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 136347-48-3
1-[3-(4-fluoro-phenyl)-5-methyl-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-piperidine

: 1374672-74-8
5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / methanol / 6 h / Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere

2.2: 1 h / -75 - 20 °C

3.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; lithium hydroxide monohydrate; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1-(4-Fluoro-phenyl)-4-methyl-1H-[1,2,3]-triazole

: 1374672-74-8
5-[3-(4-Fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-pyrazine-2-carboxylic acid (tetrahydro-pyran-4-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -75 °C / Inert atmosphere

1.2: 1 h / -75 - 20 °C

2.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 16.5 h / 0 - 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 0.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; lithium hydroxide monohydrate; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; mineral oil;