N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

Base Information

Chemical Name:N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide
CAS No.:859163-71-6
Molecular Formula:C₂₆H₂₄ClN₃O₅S
Molecular Weight:526.013
Hs Code.:

Synonyms:N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

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Technology Process of N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

There total 4 articles about N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 859163-70-5
N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

: 67515-49-5
1-benzyloxyallene

: 859163-71-6
N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

Guidance literature:: With triethylamine; palladium diacetate; In acetonitrile; at 20 ℃; for 2h;
DOI:10.1021/jo050503t

Reference yield:

: 98993-95-4
5-chloro-3-(2-nitrovinyl)indole

: 859163-71-6
N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

2: 75 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

3: 83 percent / Et₃N / Pd(OAc)2 / acetonitrile / 2 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo050503t

Reference yield:

: 827-01-0
5-chloro-1H-indole-3-carboxaldehyde

: 859163-71-6
N-(1-benzyloxyallyl)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-4-nitrobenzenesulfonylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / ammonium acetate / 2 h / Heating

2: 99 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

3: 75 percent / Et₃N / CH₂Cl₂ / 6 h / 20 °C

4: 83 percent / Et₃N / Pd(OAc)2 / acetonitrile / 2 h / 20 °C

With ammonium acetate; lithium aluminium tetrahydride; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo050503t