phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

Base Information

• Chemical Name: phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate
• CAS No.: 1310410-01-5
• Molecular Formula: C₂₄H₂₃N₃O₃S
• Molecular Weight: 433.531
• Mol file: 1310410-01-5.mol

Synonyms:phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

Chemical Property of phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate

There total 4 articles about phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]piperidine (1003639-38-0) + phenyl chloroformate (1885-14-9) → phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate (1310410-01-5)

Guidance literature:

With triethylamine; In dichloromethane; at -5 - 20 ℃; for 2.58333h;

Reference yield:

tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate (869901-02-0) → phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate (1310410-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 1 h / 60 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2.58 h / -5 - 20 °C

With hydrogenchloride; hydroxylamine; triethylamine; In diethyl ether; ethanol; dichloromethane; water;

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → phenyl 4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]-1-piperidinecarboxylate (1310410-01-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine / ethanol; water / 1 h / 60 °C

1.2: 3 h / 20 °C

2.1: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 2.58 h / -5 - 20 °C

With hydrogenchloride; hydroxylamine; triethylamine; In diethyl ether; ethanol; dichloromethane; water;

upstream raw materials:

styrene

4-[4-(4,5-dihydro-5-phenyl-3-isoxazolyl)-2-thiazolyl]piperidine

phenyl chloroformate

tert-butyl 4-(4-formyl-1,3-thiazol-2-yl)tetrahydro-1(2H)-pyridinecarboxylate