2-(Allyloxy)-5-fluorobenzaldehyde

Base Information

• Chemical Name: 2-(Allyloxy)-5-fluorobenzaldehyde
• CAS No.: 187225-94-1
• Molecular Formula: C₁₀H₉FO₂
• Molecular Weight: 180.179
• DSSTox Substance ID: DTXSID201270941

Synonyms:2-(allyloxy)-5-fluorobenzaldehyde;SCHEMBL15544576;LUGDHVFFUCSIEV-UHFFFAOYSA-N;DTXSID201270941;187225-94-1;5-Fluoro-2-(2-propen-1-yloxy)benzaldehyde

Chemical Property of 2-(Allyloxy)-5-fluorobenzaldehyde

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.05865769
• Heavy Atom Count: 13
• Complexity: 182

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C=CCOC1=C(C=C(C=C1)F)C=O

Technology Process of 2-(Allyloxy)-5-fluorobenzaldehyde

There total 1 articles about 2-(Allyloxy)-5-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-fluoro-2-hydroxybenzaldehyde (347-54-6) + allyl bromide (106-95-6) → 5-fluoro-2-(prop-2-en-1-yloxy)benzaldehyde (187225-94-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

DOI:10.1002/anie.201101220

Reference yield: 93.0%

1,1,3‐tribromo‐2,2‐dimethylcyclopropane (23534-97-6) + 5-fluoro-2-(prop-2-en-1-yloxy)benzaldehyde (187225-94-1) → (3,3-dimethylcycloprop-1-en-1-yl)[5-fluoro-2-(prop-2-en-1-yloxy)phenyl]methanol (1314234-70-2)

Guidance literature:

1,1,3‐tribromo‐2,2‐dimethylcyclopropane; With n-butyllithium; In hexanes; diethyl ether; at -78 - -10 ℃; for 1h;

5-fluoro-2-(prop-2-en-1-yloxy)benzaldehyde; In hexanes; diethyl ether; at -50 - -10 ℃; for 0.25h;

With ammonium chloride; In hexanes; diethyl ether; water; Saturated solution;

DOI:10.1002/anie.201101220

Reference yield: 90.0%

sodium 4-methylbenzenesulfinate (824-79-3) + 5-fluoro-2-(prop-2-en-1-yloxy)benzaldehyde (187225-94-1) → 6-fluoro-3-((tosyl)methyl)benzopyran-4-one

Guidance literature:

With dipotassium peroxodisulfate; iron(III) chloride hexahydrate; at 60 ℃; for 6h; Sealed tube;

upstream raw materials:

5-fluoro-2-hydroxybenzaldehyde

allyl bromide

Downstream raw materials:

(3aS,9bR)-8-Fluoro-1-((R)-1-phenyl-ethyl)-1,3a,4,9b-tetrahydro-3H-chromeno[4,3-c]isoxazole

(3,3-dimethylcycloprop-1-en-1-yl)[5-fluoro-2-(prop-2-en-1-yloxy)phenyl]methanol

(±)-4-(2-allyloxy-5-fluoro-phenyl)-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine

5-fluoro-2-hydroxy-3-(2-propenyl)benzaldehyde

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