5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Base Information

Chemical Name:5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide
CAS No.:329923-33-3
Molecular Formula:C₂₄H₂₂ClN₅O₄S
Molecular Weight:511.989
Hs Code.:

Synonyms:5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

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Chemical Property of 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

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Technology Process of 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

There total 5 articles about 5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-isopropyl pyridine-2-sulfonamide potassium salt

: 150727-72-3
4,6-dichloro-5-(o-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidine

: 329923-33-3
5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Guidance literature:: With acetic acid; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 6345-27-3,42518-06-9,61875-64-7
4-amidinopyridine hydrochloride

: 329923-33-3
5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: NaOMe / methanol / 18 h / 20 °C

2: POCl₃; PhNMe₂ / 120 °C

3: dimethylsulfoxide / 20 - 60 °C

With sodium methylate; N,N-dimethyl-aniline; trichlorophosphate; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3

Reference yield:

: 150728-08-8
5-(o-methoxyphenoxy)-4,6-dihydroxy-2-(pyridin-4-yl)-pyrimidine

: 329923-33-3
5-isopropyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃; PhNMe₂ / 120 °C

2: dimethylsulfoxide / 20 - 60 °C

With N,N-dimethyl-aniline; trichlorophosphate; In dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3