(E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

Base Information

• Chemical Name: (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one
• CAS No.: 179003-85-1
• Molecular Formula: C₂₂H₂₂O₅
• Molecular Weight: 366.414
• Mol file: 179003-85-1.mol

Synonyms:(E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

Chemical Property of (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

There total 10 articles about (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-acetyl-5-hydroxy-2,2-dimethylchromene (24672-84-2) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one (179003-85-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 25 ℃; for 36h;

DOI:10.1080/00397919908085964

Reference yield: 70.0%

6-Acetyl-5-hydroxy-2,2-dimethyl-3,4-dihydro-2H-<1>-benzopyran (51619-60-4) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one (179003-85-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2019.02.014

Reference yield:

C24H26O6 → (E)-3-(3,4-dimethoxyphenyl)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one (179003-85-1)

Guidance literature:

With hydrogenchloride; water; In methanol; at 65 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.05.005

upstream raw materials:

6-acetyl-5-hydroxy-2,2-dimethylchromene

3,4-dimethoxy-benzaldehyde

2,4-Dihydroxy-3-C-prenylacetophenone

2',4'-dihydroxy-4-acetophenone

Downstream raw materials:

3-(3,4-dimethoxyphenyl)-8,8-dimethyl-4-oxo-4H,8H-benzo[1,2-b:3,4-b']dipyran