(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Base Information

Chemical Name:(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone
CAS No.:1354826-25-7
Molecular Formula:C₂₇H₂₄F₃N₃O₃S
Molecular Weight:527.567
Hs Code.:

Synonyms:(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

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Chemical Property of (2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Chemical Property:

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Technology Process of (2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

There total 9 articles about (2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1354826-24-6
(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

: 1354826-25-7
(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 10 ℃; Inert atmosphere;

Reference yield:

: 26908-35-0
5-chloro-2-nitrobenzaldehyde ethylene acetal

: 1354826-25-7
(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

3.2: 4.5 h / -80 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

4.2: 1 h / -80 - -20 °C

5.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; oxalyl dichloride; water; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 13544-43-9
6-(trifluoromethyl)-1H-indole

: 1354826-25-7
(2-amino-5-(piperidin-1-yl)phenyl)-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

2.2: 4.5 h / -80 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

3.2: 1 h / -80 - -20 °C

4.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;