(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Base Information

Chemical Name:(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone
CAS No.:1354826-24-6
Molecular Formula:C₂₇H₂₂F₃N₃O₅S
Molecular Weight:557.55
Hs Code.:

Synonyms:(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

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Chemical Property of (2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

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Technology Process of (2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

There total 8 articles about (2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354826-23-5
(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanol

: 1354826-24-6
(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: (2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -80 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -80 - -20 ℃; for 1h;

Reference yield:

: 113259-79-3
5-(piperidin-1-yl)-2-nitrobenzaldehyde

: 1354826-24-6
(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

1.2: 4.5 h / -80 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

2.2: 1 h / -80 - -20 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 26908-35-0
5-chloro-2-nitrobenzaldehyde ethylene acetal

: 1354826-24-6
(2-nitro-5-(piperidin-1-yl)phenyl)(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Reflux

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

3.2: 4.5 h / -80 - 20 °C

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

4.2: 1 h / -80 - -20 °C

With hydrogenchloride; n-butyllithium; oxalyl dichloride; water; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;