Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester

Base Information

• Chemical Name: Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester
• CAS No.: 66831-30-9
• Molecular Formula: C₄₀H₅₁N₅O₉
• Molecular Weight: 745.873

Synonyms:Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester

Chemical Property of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester

Chemical Property:

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Technology Process of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester

There total 5 articles about Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Tyr-OH (3978-80-1) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester (66831-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C

2: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h

3: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1135/cccc19851329

Reference yield:

Tert-butyloxycarbonyltyrosyl-glycyl-glycine Benzyl Ester (60566-43-0) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester (66831-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h

2: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

With hydrogen; dicyclohexyl-carbodiimide; palladium; In chloroform; tert-butyl alcohol;

DOI:10.1135/cccc19851329

Reference yield:

L-phenylalanyl-L-leucine benzyl ester (63649-15-0) + tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine (59481-76-4) → Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucine Benzyl Ester (66831-30-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; at -20 - 0 ℃; for 3h; Yield given; r.t., overnight;

DOI:10.1135/cccc19851329

upstream raw materials:

L-phenylalanyl-L-leucine benzyl ester

tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine

Z(OMe)-Gly-Gly-Phe-Leu-OBzl

Boc-Tyr-ONB

Downstream raw materials:

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

Boc-Tyr-Gly-Gly-Phe-Leu-NHNH₂

Leu-enkephalin

Tert-butyloxycarbonylmethionyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucine

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