benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Base Information

Chemical Name:benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide
CAS No.:1338821-19-4
Molecular Formula:C₂₃H₂₆FN₃O₄S
Molecular Weight:459.542
Hs Code.:

Synonyms:benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

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Chemical Property of benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

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Technology Process of benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

There total 7 articles about benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338820-96-4
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-oxo-2-thia-1,8-diazaspiro[4.5]decane-8-carboxylate 2,2-dioxide

: 74-89-5
methylamine

: 1338821-19-4
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-oxo-2-thia-1,8-diazaspiro[4.5]decane-8-carboxylate 2,2-dioxide; methylamine; With acetic acid; In methanol; 1,2-dichloro-ethane; for 0.333333h;

With sodium tris(acetoxy)borohydride; In methanol; 1,2-dichloro-ethane;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1338821-19-4
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 18 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

3: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

4: hydrogenchloride; water / methanol / 0.5 h

5: acetic acid / methanol; 1,2-dichloro-ethane / 0.33 h

With 2,6-dimethylpyridine; hydrogenchloride; water; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1338821-19-4
benzyl (5R,7S)-1-(3-fluorophenyl)-7-methyl-4-(methylamino)-2-thia-1,8-diazaspiro[4.5]dec-3-ene-8-carboxylate 2,2-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

2: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

3: hydrogenchloride; water / methanol / 0.5 h

4: acetic acid / methanol; 1,2-dichloro-ethane / 0.33 h

With 2,6-dimethylpyridine; hydrogenchloride; water; acetic acid; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane;