(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

Base Information

Chemical Name:(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one
CAS No.:194151-64-9
Molecular Formula:C₂₈H₂₈FN₃O₅
Molecular Weight:505.546
Hs Code.:

Synonyms:(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

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Chemical Property of (R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

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Technology Process of (R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

There total 9 articles about (R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 194151-64-9
(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / K₂CO₃ / acetone

2: 96 percent / NaH / dimethylformamide

3: 86 percent / H₂, AcOH / Pd/C / methanol

4: 38 percent / 3,5-dichloro-N-fluoropyridinium triflate / CH₂Cl₂

5: PPH₃, DEAD / tetrahydrofuran

6: aq. NaOH / methanol

7: EDC, HOBT, i-Pr₂NEt / dimethylformamide

With sodium hydroxide; hydrogen; sodium hydride; 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate; potassium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(98)00568-X

Reference yield:

: 28478-45-7
methyl 4-benzyloxy-2-methoxybenzoate

: 194151-64-9
(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / H₂, AcOH / Pd/C / methanol

2: 38 percent / 3,5-dichloro-N-fluoropyridinium triflate / CH₂Cl₂

3: PPH₃, DEAD / tetrahydrofuran

4: aq. NaOH / methanol

5: EDC, HOBT, i-Pr₂NEt / dimethylformamide

With sodium hydroxide; hydrogen; 1-fluoro-3,5-dichloropyridinium trifluoromethanesulfonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00568-X

Reference yield:

: 5427-29-2
methyl 2-hydroxy-4-benzyloxybenzoate

: 194151-64-9
(R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / NaH / dimethylformamide

2: 86 percent / H₂, AcOH / Pd/C / methanol

3: 95 percent / aq. NaOH / methanol

4: 95 percent / EDC, HOBT, i-Pr₂NEt / dimethylformamide

5: Cs₂CO₃ / dimethylformamide

With sodium hydroxide; hydrogen; sodium hydride; benzotriazol-1-ol; caesium carbonate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00568-X