POTASSIUM THIOCYANATE-14C

Base Information

• Chemical Name: POTASSIUM THIOCYANATE-14C
• CAS No.: 38527-79-6
• Molecular Formula: CNS*K
• Molecular Weight: 99.171
• Mol file: 38527-79-6.mol

Synonyms:potassium [¹⁴C]-thiocyanate

Chemical Property of POTASSIUM THIOCYANATE-14C

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

POTASSIUM THIOCYANATE[14C] 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,R
• Statements: 20/21/22-32-52/53
• Safety Statements: 13-61

MSDS Files:

Useful:

Technology Process of POTASSIUM THIOCYANATE-14C

There total 2 articles about POTASSIUM THIOCYANATE-14C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium [14C]cyanide → potassium [14C]-thiocyanate (38527-79-6)

Guidance literature:

With sulfur; In acetone; at 75 ℃; for 2.08333h;

DOI:10.1002/cmdc.201900478 DOI:10.1021/acs.jmedchem.0c01917

Reference yield:

potassium [14C]cyanide + potassium thioacyanate (333-20-0) → potassium cyanide + potassium [14C]-thiocyanate (38527-79-6)

Guidance literature:

In water; by pH=11.1-14.0;

DOI:10.1021/ja01126a502

Reference yield: 95.0%

benzoyl chloride (98-88-4) + potassium [14C]-thiocyanate (38527-79-6) → benzoyl [14C]-isothiocyanate

Guidance literature:

In acetonitrile; at 70 ℃; for 1h;

DOI:10.1002/jlcr.2951

upstream raw materials:

potassium thioacyanate

Downstream raw materials:

Diphenylthiophosphinigsaeure-<¹⁴C>-isothiocyanat

(S)-benzyl [2-¹⁴C]-2-amino-7,8-dihydro-6Hindeno[5,4-d]thiazol-7-yl(ethyl)carbamate

(R)-benzyl [2-¹⁴C]-2-amino-6,7-dihydro-5H-indeno[5,6-d]thiazol-6-yl(ethyl)carbamate

Refernces

• 1、 Koriyama, Yuji,Hori, Akihiro,Ito, Hisanori,Yonezawa, Shuji,Baba, Yoshiyasu,Tanimoto, Norihiko,Ueno, Tatsuhiko,Yamamoto, Shiho,Yamamoto, Takahiko,Asada, Naoya,Morimoto, Kenji,Einaru, Shunsuke,Sakai, Katsunori,Kanazu, Takushi,Matsuda, Akihiro,Yamaguchi, Yoshitaka,Oguma, Takuya,Timmers, Maarten,Tritsmans, Luc,Kusakabe, Ken-Ichi,Kato, Akira,Sakaguchi, Gaku. "Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial". supporting information. p. 1873 - 1888. Retrieved 2021/03/01.