(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

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Chemical Name:(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid
CAS No.:1026654-85-2
Molecular Formula:C₄₀H₆₄N₄O₉Si₂
Molecular Weight:801.141
Hs Code.:

(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Synonyms:(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

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Chemical Property of (S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

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Technology Process of (S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

There total 12 articles about (S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 184295-96-3
(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

: 1026654-85-2
(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/ja962859f

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 1026654-85-2
(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: Multi-step reaction with 9 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.25 h / -15 °C

2: CH₂Cl₂ / 0 - 20 °C

3: imidazole / CH₂Cl₂

4: H₂ / Pd/C / methanol

5: CH₂Cl₂ / 0 - 20 °C

6: imidazole / CH₂Cl₂

7: H₂ / Pd/C / methanol / 2 h

8: CH₂Cl₂ / 1 h / 0 - 20 °C

9: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja962859f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1026654-85-2
(S)-2-{(R)-2-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionylamino]-3-phenyl-propionylamino}-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / CH₂Cl₂

2: H₂ / Pd/C / methanol

3: CH₂Cl₂ / 0 - 20 °C

4: imidazole / CH₂Cl₂

5: H₂ / Pd/C / methanol / 2 h

6: CH₂Cl₂ / 1 h / 0 - 20 °C

7: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; lithium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja962859f