2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

Base Information

Chemical Name:2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline
CAS No.:188255-05-2
Molecular Formula:C₄₄H₃₅N₅O₂
Molecular Weight:665.794
Hs Code.:

Synonyms:2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

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Chemical Property of 2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

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Technology Process of 2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

There total 7 articles about 2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 124993-40-4
2-[(4-hydroxyphenoxy)methyl]quinoline

: 188255-03-0
5-(2-Bromomethyl-benzyl)-2-trityl-2H-tetrazole

: 188255-05-2
2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

Guidance literature:: With potassium fluoride on basic alumina; In acetonitrile; at 50 ℃; for 5h;
DOI:10.1016/S0040-4039(96)02460-4

Reference yield:

: 19820-77-0
quinolin-2-ylmethyl 4-methylbenzenesulfonate

: 188255-05-2
2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NaOH / methanol; acetonitrile

2: 83 percent / KF*alumina / acetonitrile / 5 h / 50 °C

With sodium hydroxide; potassium fluoride on basic alumina; In methanol; acetonitrile;
DOI:10.1016/S0040-4039(96)02460-4

Reference yield:

: 67519-22-6
α-hydroxy-α'-cyano-o-xylene

: 188255-05-2
2-{4-[2-(2-Trityl-2H-tetrazol-5-ylmethyl)-benzyloxy]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / NaN₃, Et₃N*HCl, NMP / 20 h / 120 °C

2: 95 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: 85 percent / NBS, Me₂S / CH₂Cl₂ / 3 h / 0 °C

4: 83 percent / KF*alumina / acetonitrile / 5 h / 50 °C

With pyridine; 1-methyl-pyrrolidin-2-one; potassium fluoride on basic alumina; N-Bromosuccinimide; sodium azide; dimethylsulfide; triethylamine hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(96)02460-4