N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

Base Information

Chemical Name:N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide
CAS No.:1450789-84-0
Molecular Formula:C₄₀H₃₅F₃N₆O₈S
Molecular Weight:816.815
Hs Code.:

N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

Synonyms:N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

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Chemical Property of N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

There total 9 articles about N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 15159-40-7
4-morpholinocarbonyl chloride

: 1450789-81-7
3-(2-amino-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

: 1450789-84-0
N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 40 ℃; pH=> 10;
DOI:10.1021/ml400217r

Reference yield:

: 1450789-66-8
2-((tert-butoxycarbonyl)amino)-2-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)acetic acid

: 1450789-84-0
N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C / pH > 10

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: triethylamine / dichloromethane / 40 °C / pH > 10

With hydrogenchloride; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml400217r

Reference yield:

: 591-19-5
m-Bromoaniline

: 1450789-84-0
N-(1-(4-((6-methoxy-2-phenylpyrimidin-4-yl)oxy)-3-vinylphenyl)-2-oxo-2-((3-(((4-(trifluoromethyl)phenyl)sulfonyl)carbamoyl)phenyl)amino)ethyl)morpholine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tri tert-butylphosphoniumtetrafluoroborate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 25 h / 140 °C / Microwave irradiation

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C / pH > 10

3: hydrogenchloride / 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 40 °C / pH > 10

With hydrogenchloride; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ml400217r