Technology Process of MIDA ((4-fluorophenyl)oxomethyl)boronate
There total 7 articles about MIDA ((4-fluorophenyl)oxomethyl)boronate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane; water;
at 23 ℃;
DOI:10.1002/anie.201206501
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tricyclohexylphosphine; palladium diacetate; 2,2,2-trifluoroethanol; bromobenzene / toluene / 3 h / 60 °C / Inert atmosphere; Darkness
2: ammonium acetate; sodium periodate / acetone; water / 2 h / 80 °C / Reflux
3: toluene; dimethyl sulfoxide / 2 h / 105 °C
4: 4-methylmorpholine N-oxide; osmium(VIII) oxide / acetone; aq. phosphate buffer / 20 °C / Darkness
5: sodium periodate / dichloromethane; water / 0.17 h / 20 °C
With
sodium periodate; osmium(VIII) oxide; bromobenzene; 2,2,2-trifluoroethanol; ammonium acetate; palladium diacetate; 4-methylmorpholine N-oxide; tricyclohexylphosphine;
In
aq. phosphate buffer; dichloromethane; water; dimethyl sulfoxide; acetone; toluene;
4: |Upjohn Dihydroxylation / 5: |Malaprade-Lemieux-Johnson Cleavage;
DOI:10.1016/j.tetlet.2021.153147
