Multi-step reaction with 9 steps
1: triethylamine / 1 h / 50 °C
2: hydrogen / Raney-Ni / ethanol
3: sodium carbonate / tetrahydrofuran; water / 1.17 h / 0 °C
4: potassium tert-butylate / tert-butyl alcohol / 1 h / Reflux
5: diethylamino-sulfur trifluoride / dichloromethane / 0 °C
6: Lawessons reagent / tetrahydrofuran / 1 h / 50 °C
7: tert.-butylhydroperoxide; ammonium hydroxide; ammonia / methanol; water / 2 h
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h
9: sodium azide; sodium L-ascorbate / copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane / ethanol; water / 1 h / 90 °C / Inert atmosphere
With
Lawessons reagent; tert.-butylhydroperoxide; ammonium hydroxide; sodium azide; diethylamino-sulfur trifluoride; potassium tert-butylate; ammonia; hydrogen; sodium carbonate; sodium L-ascorbate; triethylamine; N-ethyl-N,N-diisopropylamine;
copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;