2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Base Information

Chemical Name:2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine
CAS No.:762275-97-8
Molecular Formula:C₂₆H₂₆N₂O₃
Molecular Weight:414.504
Hs Code.:

Synonyms:2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

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Chemical Property of 2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

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Technology Process of 2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

There total 7 articles about 2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74-88-4
methyl iodide

: 1019636-97-5
2-(4-benzyloxy-5-hydroxy-2-methoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

: 762275-97-8
2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: With dibenzo-18-crown-6; In acetonitrile;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 52249-86-2
2-benzyloxy-4-methoxyacetophenone

: 762275-97-8
2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: NBS; silica gel / CCl₄

2.1: MCPBA / CH₂Cl₂

3.1: imidazole / tetrahydrofuran

4.1: BuLi / tetrahydrofuran / -78 °C

4.2: B(OEt)3 / tetrahydrofuran

5.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

6.1: KF; aq. HBr

7.1: dibenzo-18-crown-6 / acetonitrile

With 1H-imidazole; potassium fluoride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzo-18-crown-6; n-butyllithium; hydrogen bromide; silica gel; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile; 2.1: Baeyer-Villiger oxidation / 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 100-39-0
benzyl bromide

: 762275-97-8
2-(4-benzyloxy-2,5-dimethoxy-phenyl)-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: KOH; dibenzo-18-crown-6 / acetonitrile

2.1: NBS; silica gel / CCl₄

3.1: MCPBA / CH₂Cl₂

4.1: imidazole / tetrahydrofuran

5.1: BuLi / tetrahydrofuran / -78 °C

5.2: B(OEt)3 / tetrahydrofuran

6.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

7.1: KF; aq. HBr

8.1: dibenzo-18-crown-6 / acetonitrile

With 1H-imidazole; potassium fluoride; potassium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzo-18-crown-6; n-butyllithium; hydrogen bromide; silica gel; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile; 3.1: Baeyer-Villiger oxidation / 6.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043