<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

Base Information

• Chemical Name: <3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone
• CAS No.: 125816-10-6
• Molecular Formula: C₁₅H₂₇NO₂
• Molecular Weight: 253.385
• Mol file: 125816-10-6.mol

Synonyms:<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

Chemical Property of <3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone

There total 45 articles about <3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

<3S-<3α,5β(R*)>>-5-(2-Cyclohexyl-1-azidoethyl)dihydro-3-isopropyl-2(3H)-furanone (118041-20-6) → <3S-<3α,5β(R*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone (125816-10-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; under 760 Torr;

DOI:10.1021/jm00171a006

Reference yield:

(3S,5S,6S)-6-Cyclohexyl-5-hydroxy-3-isopropyl-piperidin-2-one → <3S-<3α,5β(R*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone (125816-10-6)

Guidance literature:

With sodium hydrogencarbonate; In hydrogenchloride; ethanol; water;

Reference yield:

(4S)-4-benzyl-3-<(2S,4E)-6-cyclohexyl-2-isopropylhex-4-enoyl>oxazolidin-2-one (128948-72-1) → <3S-<3α,5β(R*)>>-5-(2-Cyclohexyl-1-aminoethyl)dihydro-3-isopropyl-2(3H)-furanone (125816-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NBS / H₂O; 1,2-dimethoxy-ethane / 0 deg C, 10 min, then room temp., overnight

2: NaN₃ / various solvent(s) / 20 °C

3: H₂ / Pd/C / ethanol

With N-Bromosuccinimide; sodium azide; hydrogen; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; water;

DOI:10.1016/S0040-4039(01)80674-2

upstream raw materials:

<3S-<3α,5β(R^*)>>-5-(2-Cyclohexyl-1-azidoethyl)dihydro-3-isopropyl-2(3H)-furanone

(3S,5S,6S)-6-Cyclohexylmethyl-5-hydroxy-3-isopropylpiperidin-2-one

(3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one

methyl 3-methyl-2-ketobutanoate

Downstream raw materials:

(1S,3'S,5'S)-N-(2-cyclohexyl-1-(3-isopropyl-2-oxo-2,3,4,5-tetrahydrofuran-5-yl)ethyl)-(1S)-(1-((4-(methoxymethoxy)piperidin-1-yl)carbonyl)-2-phenylethyl)-L-norleucinamide

<2S,4S,5S>-6-Cyclohexyl-5-<(N-cyclohexyl-N-methyl)glycyl-3-(1-naphthyl)-L-alanyl-3-(4-thiazolyl)-L-alanyl)amino>-4-hydroxy-2-isopropylhexanoyl-<2-(4-morpholino)ethyl>amide

(2S,3S,5S)-2-benzyloxycarbonylamino-1-cyclohexyl-5-isopropylhexane-3,6-diol

(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[(R)-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid (2-dimethylamino-ethyl)-amide