N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide

Base Information

• Chemical Name: N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide
• CAS No.: 140413-39-4
• Molecular Formula: C₁₄H₁₁ClN₂O₄
• Molecular Weight: 306.705
• Mol file: 140413-39-4.mol

Synonyms:N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide

Chemical Property of N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide

There total 4 articles about N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-chloro-5-nitrobenzoylchloride (25784-91-2) + 3-amino-4-hydroxytoluene (95-84-1) → N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide (140413-39-4)

Guidance literature:

With hydrogenchloride; triethylamine; In tetrahydrofuran;

Reference yield: 85.0%

2-chloro-5-nitrobenzoic acid (2516-96-3) + 2-Hydroxy-4-methylanilin (2835-98-5) → N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide (140413-39-4)

Guidance literature:

2-chloro-5-nitrobenzoic acid; With thionyl chloride; In N,N-dimethyl-formamide; Reflux;

2-Hydroxy-4-methylanilin; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 48h; Cooling;

Reference yield:

2-chloro-5-nitrobenzoylchloride (25784-91-2) + 2-Hydroxy-4-methylanilin (2835-98-5) → N-(2-hydroxy-4-methylphenyl)-2-chloro-5-nitrobenzenecarboxamide (140413-39-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 25 ℃; for 48h; Yield given;

DOI:10.1021/jm00088a027

upstream raw materials:

2-chloro-5-nitrobenzoylchloride

2-Hydroxy-4-methylanilin

2-chloro-5-nitrobenzoic acid

3-amino-4-hydroxytoluene

Downstream raw materials:

2-Amino-7-methyl-10-propyl-10H-dibenzo[b,f][1,4]oxazepin-11-one

7,10-Dimethyl-11-oxo-10,11-dihydro-dibenzo[b,f][1,4]oxazepine-2-carbonitrile

2-amino-7,10-dimethyldibenz<1,4>oxazepin-11(10H)-one

7,10-Dimethyl-10H-dibenzo[b,f][1,4]oxazepin-11-one