tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

Base Information

Chemical Name:tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate
CAS No.:1239956-72-9
Molecular Formula:C₃₁H₂₉Cl₂F₃N₂O₃S
Molecular Weight:637.55
Hs Code.:

Synonyms:tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

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Chemical Property of tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

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Technology Process of tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

There total 5 articles about tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1239964-18-1
tert-butyl 3,5-difluoro-4-[(methanesulfonyloxy)methyl]benzoate

: 1239963-87-1
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazole-2-thiol

: 1239956-72-9
tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 1.25h;

Reference yield:

: 455-40-3
3,5-difluorobenzoic acid

: 1239956-72-9
tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; magnesium sulfate / toluene / 20 °C

2: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 3 h / -78 °C

3: sodium tetrahydroborate / methanol / 0.33 h / 0 °C

4: triethylamine / dichloromethane / 0.5 h / 0 °C

5: potassium carbonate / acetone / 1.25 h / 20 °C

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; magnesium sulfate; potassium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexanes; dichloromethane; acetone; toluene;

Reference yield:

: 1239964-17-0
tert-butyl 3,5-difluoro-4-(hydroxymethyl)benzoate

: 1239956-72-9
tert-butyl 4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluoro-3-methoxyphenyl)-1H-imidazol-2-ylthio)methyl)-3,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 °C

2: potassium carbonate / acetone / 1.25 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetone;