1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Base Information

Chemical Name:1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea
CAS No.:1315326-83-0
Molecular Formula:C₄₀H₄₇N₇O₈S₂
Molecular Weight:817.987
Hs Code.:

1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Synonyms:1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Suppliers and Price of 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

There total 11 articles about 1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1315326-82-9
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxy-phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1315326-83-0
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-N-((2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)-4-(2-(4-isopropoxy-phenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidine-2-carboxamide hydrochloride salt; 1,1'-Thiocarbonyldiimidazole; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With ammonia; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 3h;

Reference yield:

: 54802-10-7
3-aminobenzofuran-2-carboxamide

: 1315326-83-0
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / tetrahydrofuran / 0 - 20 °C

2.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

2.2: pH ~ 2

3.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C

3.2: pH ~ 9

4.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C

4.2: 1 h / 20 °C

4.3: pH ~ 3

5.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 20 °C

6.1: thionyl chloride / methanol / 2 h / 0 - 45 °C

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 5 h / 20 °C

8.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 5.5 h / 0 °C

9.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

9.2: 3 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; tert-butyl alcohol;

Reference yield:

: 611-20-1
salicylonitrile

: 1315326-83-0
1-((S)-1-((2S,4R)-2-(((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropyl)carbamoyl)-4-(2-(4-isopropoxyphenyl)benzofuro[3,2-d]pyrimidin-4-yloxy)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)thiourea

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

1.2: 3 h / 80 °C

2.1: potassium tert-butylate / tert-butyl alcohol / 3 h / 80 °C

3.1: pyridine / tetrahydrofuran / 0 - 20 °C

4.1: potassium tert-butylate / water; tert-butyl alcohol / 70 °C

4.2: pH ~ 2

5.1: trichlorophosphate / 1,4-dioxane / 2 h / 0 - 110 °C

5.2: pH ~ 9

6.1: sodium t-butanolate / dimethylsulfoxide-d6 / 2 h / 0 - 20 °C

6.2: 1 h / 20 °C

6.3: pH ~ 3

7.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 6 h / 0 - 20 °C

8.1: thionyl chloride / methanol / 2 h / 0 - 45 °C

9.1: benzotriazol-1-ol; 4-methyl-morpholine; HATU / dichloromethane / 5 h / 20 °C

10.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 5.5 h / 0 °C

11.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

11.2: 3 h / 0 - 20 °C

With 4-methyl-morpholine; pyridine; hydrogenchloride; thionyl chloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; triethylamine; HATU; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dimethylsulfoxide-d6; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;