(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

Base Information

Chemical Name:(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine
CAS No.:175430-80-5
Molecular Formula:C₂₂H₃₈N₂OSi
Molecular Weight:374.642
Hs Code.:

Synonyms:(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

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Chemical Property of (+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

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Technology Process of (+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

There total 3 articles about (+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 100-39-0
benzyl bromide

: 175430-71-4
(+)-(2S)-1-<1'-(t-Butyldimethylsilyl)prop-2'-ylideneamino>-2-methoxymethylpyrrolidine

: 175430-80-5
(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

Guidance literature:: With n-butyllithium; diisopropylamine; In diethyl ether; hexane; 1.) 0 deg C, 4 h; -78 deg C, 0.5 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.;

Reference yield:

: 65651-52-7
(S)-(+)-2-methoxymethyl-1-(1-methylethylideneamino)pyrrolidine

: 175430-80-5
(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LDA / tetrahydrofuran / 1.) 0 deg C, 4 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

2: 83 percent / n-BuLi, diisopropylamine / diethyl ether; hexane / 1.) 0 deg C, 4 h; -78 deg C, 0.5 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 175430-80-5
(+)-(2S,3'S)-1-<2'-(t-Butyldimethylsilyl)-1'-phenylbut-3'-ylideneamino>-2-methoxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LDA / tetrahydrofuran / 1.) 0 deg C, 4 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

2: 83 percent / n-BuLi, diisopropylamine / diethyl ether; hexane / 1.) 0 deg C, 4 h; -78 deg C, 0.5 h, 2.) -78 deg C, 1 h; -78 deg C -> room temp.

With n-butyllithium; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;