ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

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Chemical Name:ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate
CAS No.:1448992-24-2
Molecular Formula:C₂₇H₂₇ClFN₅O₂
Molecular Weight:507.995
Hs Code.:

Synonyms:ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

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Chemical Property of ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

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Technology Process of ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

There total 5 articles about ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1448992-18-4
2-chloro-4-(4-fluorophenyl)-6-methylpyrimidine-5-carboxylic acid ethyl ester

: 53186-45-1
N₁-(7-chloroquinolin-4-yl)butane-1,4-diamine

: 1448992-24-2
ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Reflux;
DOI:10.1016/j.ejmech.2013.05.046

Reference yield:

: 5937-24-6
ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1448992-24-2
ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: nitric acid / 0.5 h / 0 °C

2: trichlorophosphate / 0.75 h / 105 °C

3: potassium carbonate / acetonitrile / 24 h / Reflux

With nitric acid; potassium carbonate; trichlorophosphate; In acetonitrile;
DOI:10.1016/j.ejmech.2013.05.046

Reference yield:

: 141-97-9
ethyl acetoacetate

: 1448992-24-2
ethyl 4-(4-fluorophenyl)-2-(4-((7-chloroquinolin-4-yl)amino)butylamino)-6-methylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium chloride / 3 h / 100 °C

2: nitric acid / 0.5 h / 0 °C

3: trichlorophosphate / 0.75 h / 105 °C

4: potassium carbonate / acetonitrile / 24 h / Reflux

With nitric acid; potassium carbonate; ammonium chloride; trichlorophosphate; In acetonitrile; 1: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.ejmech.2013.05.046