(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole

Base Information

• Chemical Name: (RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole
• CAS No.: 103859-00-3
• Molecular Formula: C₁₁H₁₃NS
• Molecular Weight: 191.297
• Mol file: 103859-00-3.mol

Synonyms:(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole

Chemical Property of (RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole

There total 1 articles about (RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-2-methylpropanal (13206-46-7) + benzaldehyde (100-52-7) → (RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole (103859-00-3)

Guidance literature:

With sodium hydrogensulfide; ammonia;

Reference yield: 66.0%

(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole (103859-00-3) + potassium ethyl xanthogenate (140-89-6) + acetyl chloride (75-36-5) → (4R*,2S*)-3-acetyl-4-(ethoxycarbonothioyl)thio-5,5-dimethyl-2-phenyl-1,3-thiazolidine

Guidance literature:

(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole; acetyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere; Schlenk technique; Green chemistry;

potassium ethyl xanthogenate; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1055/s-0036-1589050

Reference yield:

(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole (103859-00-3) + diisopropyl hydrogenphosphonate (1809-20-7) → rac-diisopropyl (2-phenyl-5,5-dimethyl-1,3-thiazolidin-4-yl)phosphonate + rac-diisopropyl (2-phenyl-5,5-dimethyl-1,3-thiazolidin-4-yl)phosphonate

Guidance literature:

(RS)-5,5-dimethyl-2-phenyl-2,5-dihydro-1,3-thiazole; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 1h;

diisopropyl hydrogenphosphonate; In dichloromethane; at 21 ℃; for 120h; Further stages. Title compound not separated from byproducts.;

DOI:10.1039/b101501j

upstream raw materials:

2-bromo-2-methylpropanal

benzaldehyde

Downstream raw materials:

5,5-dimethyl-2-phenyl-thiazolidine-4-carbonitrile

5,5-dimethyl-2-phenyl-thiazolidine-4-carboxylic acid amide

1-(benzylamino)-2-methylpropane-2-thiol hydrochloride