4-Hydroxy-3,5-diiodobenzaldehyde

Base Information

• Chemical Name: 4-Hydroxy-3,5-diiodobenzaldehyde
• CAS No.: 1948-40-9
• Molecular Formula: C7H4 I2 O2
• Molecular Weight: 373.917
• Hs Code.: 2913000090
• European Community (EC) Number: 217-754-3
• NSC Number: 72943
• DSSTox Substance ID: DTXSID20173129
• Nikkaji Number: J199.767J
• Wikidata: Q72467192
• Mol file: 1948-40-9.mol

Synonyms:3,5-Diiodo-4-hydroxybenzaldehyde;4-Hydroxy-3,5-diiodobenzaldehyde;1948-40-9;Benzaldehyde, 4-hydroxy-3,5-diiodo-;3,5-Diiodo4-hydroxybenzaldehyde;C7H4I2O2;EINECS 217-754-3;MFCD00014670;4-hydroxy-3,5-diiodo-benzaldehyde;NSC72943;3,5-Dijod-p-oxybenzaldehyd;NCIOpen2_008726;SCHEMBL1005116;3,5-Diiodo-4-Hydroxybenzaldhyde;DTXSID20173129;BCP33863;4-Hydroxy-3,5-diiodobenzaldehyde #;BBL023135;NSC 72943;NSC-72943;STK015966;AKOS000313088;AM84214;PS-6984;SY022938;CS-0116741;FT-0614630;H1539;EN300-345099;A813757;W-107697;Z1269228742

Chemical Property of 4-Hydroxy-3,5-diiodobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00177mmHg at 25°C
• Melting Point: 202-203°C
• Boiling Point: 284.1°C at 760 mmHg
• PKA: 4.89±0.23(Predicted)
• Flash Point: 125.6°C
• PSA: 37.30000
• Density: 2.602g/cm³
• LogP: 2.41390
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Sensitive.: Air & Light Sensitive
• Solubility.: Chloroform (Slightly, Sonicated), DMSO (Slightly)
• Water Solubility.: Insoluble in water. Sparingly soluble in chloroform and methanol.
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 373.83007
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

98% ^*data from raw suppliers

3,5-Diiodo-4-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1I)O)I)C=O
• Uses: 3,5-Diiodo-4-hydroxybenzaldehyde (cas# 1948-40-9) is a compound useful in organic synthesis.

Technology Process of 4-Hydroxy-3,5-diiodobenzaldehyde

There total 15 articles about 4-Hydroxy-3,5-diiodobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-hydroxy-3,5-diiodobenzaldehyde (1948-40-9)

Guidance literature:

With sodium periodate; sulfuric acid; iodine; potassium iodide; sodium sulfite; In water; acetic acid; at 25 ℃; for 2h; Reagent/catalyst;

DOI:10.1134/S1070428016030234

Reference yield: 92.6%

4-hydroxy-3-iodo-benzaldehyde (60032-63-5) → 4-hydroxy-3,5-diiodobenzaldehyde (1948-40-9)

Guidance literature:

With N-iodo-succinimide; In acetonitrile; at 25 - 30 ℃; for 0.416667h; regioselective reaction;

DOI:10.1016/j.tetlet.2021.153154

Reference yield: 88.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + tetraethyl ammonium → 4-hydroxy-3,5-diiodobenzaldehyde (1948-40-9)

Guidance literature:

In chloroform; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)83135-5

upstream raw materials:

chloroform

2,6-diiodo-phenol

4-hydroxy-benzaldehyde

4-(hydroxymethyl)-2,6-diiodophenol

Downstream raw materials:

3,5-diiodo-4-hydroxybenzoic acid

4-hydroxy-3,5-diiodo-benzaldehyde-oxime

4-acetoxy-3,5-diiodo-benzaldehyde

Refernces

Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents

10.1016/j.bmc.2021.116209

This research aimed to evaluate the potential of iodinated hydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents, addressing the increasing resistance of bacterial and fungal pathogens to existing treatments. The study synthesized and screened twenty-two iodinated hydrazide-hydrazones and ten 1,2-diacylhydrazines, along with their three reduced analogues, for their antibacterial, antifungal, and cytotoxic properties. The compounds were tested against eight bacterial and eight fungal strains, and their cytotoxicity was assessed on HepG2 and HK-2 cell lines. The study found that certain derivatives, particularly those containing the 3,5-diiodosalicylidene scaffold, exhibited potent antibacterial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with low minimum inhibitory concentrations (MIC) values. Some compounds also showed antifungal activity and variable degrees of cytotoxicity, with normal human cells exhibiting lower sensitivity. The research concluded that these compounds, especially those with electron-withdrawing groups like F, Cl, CF3, and NO2, have potential as antimicrobial and cytotoxic agents. The chemicals used in the process included various substituted benzohydrazides, 2-/4-hydroxy-3,5-diiodobenzaldehydes, 3,5-diiodosalicylic acid, and their derivatives, as well as reagents for biological assays and cytotoxicity tests.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1948-40-9 3,5-DIIODO-4-HYDROXYBENZALDEHYDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send