ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Base Information

Chemical Name:ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate
CAS No.:1610371-69-1
Molecular Formula:C₃₁H₃₂F₄N₂O₃
Molecular Weight:556.6
Hs Code.:

Synonyms:ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Suppliers and Price of ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

There total 16 articles about ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 74-96-4
ethyl bromide

: 1610371-19-1
ethyl 2-((4S,5S)-1-(4-((2'-fluoro-5'-hydroxy-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

: 1610371-69-1
ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: With caesium carbonate; In acetonitrile; for 1h; Reflux;

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 1610371-69-1
ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 15 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / -78 - 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

3.2: 1.33 h / 90 °C

4.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

7.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

8.1: silver carbonate / 1,4-dioxane / 41 h / 50 - 55 °C / Inert atmosphere

9.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h / 20 °C

10.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

11.1: dimethyl sulfoxide / 5.8 h / 60 °C

12.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 25 h / 20 - 35 °C

13.1: hydrogenchloride / ethyl acetate / 45 h / 20 °C

14.1: boron tribromide / dichloromethane / 4.25 h / -78 - 0 °C

15.1: caesium carbonate / acetonitrile / 1 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid methyl ester; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 24078-12-4
4-bromo-2-methylbenzaldehyde

: 1610371-69-1
ethyl 2-((4S,5S)-1-(4-((5'-ethoxy-2'-fluoro-3-methyl-[1,1'-biphenyl]-4-yl)methyl)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

Guidance literature:: Multi-step reaction with 14 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 66 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid hydrazide / 1,4-dioxane / 0.33 h / 80 °C

2.2: 1.33 h / 90 °C

3.1: caesium carbonate; 1,10-Phenanthroline; copper(l) iodide / N,N-dimethyl-formamide / 1.67 h / 80 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 4.75 h / 760.05 Torr

6.1: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

7.1: silver carbonate / 1,4-dioxane / 41 h / 50 - 55 °C / Inert atmosphere

8.1: sodium tetrahydroborate / tetrahydrofuran; water / 1.5 h / 20 °C

9.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

10.1: dimethyl sulfoxide / 5.8 h / 60 °C

11.1: hydrogenchloride / dichloromethane; acetic acid methyl ester / 25 h / 20 - 35 °C

12.1: hydrogenchloride / ethyl acetate / 45 h / 20 °C

13.1: boron tribromide / dichloromethane / 4.25 h / -78 - 0 °C

14.1: caesium carbonate / acetonitrile / 1 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,10-Phenanthroline; 5%-palladium/activated carbon; hydrogen; boron tribromide; potassium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; toluene-4-sulfonic acid hydrazide; silver carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid methyl ester; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;