(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Base Information

Chemical Name:(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile
CAS No.:1432059-83-0
Molecular Formula:C₁₈H₁₃Cl₂N₃O
Molecular Weight:358.227
Hs Code.:

Synonyms:(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Suppliers and Price of (S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

There total 8 articles about (S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 945736-71-0
(E)-1-(3-(3,4-dichlorophenyl)allyl)indoline-2,3-dione

: 7677-24-9
trimethylsilyl cyanide

: 1432059-83-0
(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Guidance literature:: (E)-1-(3-(3,4-dichlorophenyl)allyl)indoline-2,3-dione; With 3-((3,5-bis(trifluoromethyl)phenyl)amino)-4-(((S)-(6-methoxyquinoline-4-yl))((1S,2S,4S,5R-5-vinylquinuclidine-2-yl)methyl)amino)cyclobutan-3-ene-1,2-dione; 1,1,1,3,3,3-hexamethyl-disilazane; In toluene; at 20 ℃; for 48h; Inert atmosphere;

trimethylsilyl cyanide; With ethanol; In toluene; at -40 ℃; for 48h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.1c01194

Reference yield: 73.0%

: 1432059-82-9
tert-butyl (E)-(3-cyano-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindolin-3-yl)carbamate

: 1432059-83-0
(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃; for 9h; Inert atmosphere;
DOI:10.1039/c2cc36665g

Reference yield:

: 40950-94-5,82475-77-2
ethyl (E)-3-(3,4-dichloro-phenyl)-2-propenoate

: 1432059-83-0
(S,E)-3-amino-1-(3-(3,4-dichlorophenyl)allyl)-2-oxoindoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1.17 h / 0 °C / Inert atmosphere

2.1: phosphorus tribromide / diethyl ether / 2 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

4.1: toluene; 1,4-dioxane / 10 h / Sealed tube

5.1: 1,1,1,3',3',3'-hexafluoro-propanol; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea / dichloromethane / -70 °C

6.1: hydrogenchloride / ethyl acetate / 9 h / 0 °C / Inert atmosphere

With hydrogenchloride; 1-(3,5-bis(trifluoromethyl)phenyl)-3-((R)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinu clidin-2-yl)methyl)thiourea; 1,1,1,3',3',3'-hexafluoro-propanol; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: |Aza-Wittig Reaction;
DOI:10.1039/c2cc36665g