N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

Base Information

Chemical Name:N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide
CAS No.:460048-79-7
Molecular Formula:C₃₅H₅₁N₅O₆
Molecular Weight:637.82
Hs Code.:

<i>N</i>-benzyl-<i>N</i>'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

Synonyms:N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

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Chemical Property of N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

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Technology Process of N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

There total 9 articles about N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 107-85-7
1-amino-3-methylbutane

: 590-86-3
isovaleraldehyde

: 460048-60-6
formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

: 310873-79-1
N-(benzylaminocarbonylpropyl)glycine

: 460048-79-7
N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 48h;
DOI:10.1055/s-2002-31948

Reference yield:

: 100-46-9
benzylamine

: 460048-79-7
N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84.22 percent / Et₃N / CHCl₃ / 12 h / 60 °C

2: 73.9 percent / DCC / CHCl₃ / 2 h / 20 °C

3: 63 percent / H₂; HCOOH / 10 percent Pd/C / methanol / 6 h / 20 °C / 3040 Torr

4: 35 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; 4: Ugi reaction;
DOI:10.1055/s-2002-31948

Reference yield:

: 64984-60-7
4-oxo-4-[(phenylmethyl)amino]butanoic acid

: 460048-79-7
N-benzyl-N'-{[[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 73.9 percent / DCC / CHCl₃ / 2 h / 20 °C

2: 63 percent / H₂; HCOOH / 10 percent Pd/C / methanol / 6 h / 20 °C / 3040 Torr

3: 35 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With formic acid; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; 3: Ugi reaction;
DOI:10.1055/s-2002-31948