2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid

Base Information

• Chemical Name: 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid
• CAS No.: 101973-79-9
• Molecular Formula: C₁₄H₁₆O₅S
• Molecular Weight: 296.344
• Mol file: 101973-79-9.mol

Synonyms:2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid

Chemical Property of 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid

There total 3 articles about 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.5%

3-(4-methoxybenzoyl)-2-methylenepropionic acid (101973-94-8) + tiolacetic acid (507-09-5) → 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid (101973-79-9)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 30 ℃; for 2.5h;

DOI:10.1248/cpb.36.2050

Reference yield:

itaconic acid anhydride (2170-03-8) → 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid (101973-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / AlCl₃ / 1,2-dichloro-ethane

2: 61.5 percent / potassium carbonate / dimethylformamide; H₂O / 2.5 h / 30 °C

With aluminium trichloride; potassium carbonate; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.2050

Reference yield:

methoxybenzene (100-66-3) → 2-acetylsulfanylmethyl-4-(4-methoxyphenyl)-4-oxobutyric acid (101973-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / AlCl₃ / 1,2-dichloro-ethane

2: 61.5 percent / potassium carbonate / dimethylformamide; H₂O / 2.5 h / 30 °C

With aluminium trichloride; potassium carbonate; In water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.2050

upstream raw materials:

3-(4-methoxybenzoyl)-2-methylenepropionic acid

tiolacetic acid

itaconic acid anhydride

methoxybenzene