1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

Base Information

Chemical Name:1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride
CAS No.:111627-01-1
Molecular Formula:C₃₀H₃₃F₂NO₄*ClH
Molecular Weight:546.054
Hs Code.:

Synonyms:1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

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Chemical Property of 1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

Chemical Property:

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Technology Process of 1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

There total 6 articles about 1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 111627-55-5
1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 111627-01-1
1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

Guidance literature:: With sodium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00121a022

Reference yield:

: florisil

: 111627-55-5
1-[4-(3-chloropropoxy)-2-methoxyphenyl]ethanone

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 111627-01-1
1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

Guidance literature:: With potassium iodide; sodium carbonate; In butan-1-ol; benzene;

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 111627-01-1
1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 40 percent / Na₂CO₃, KI / butan-1-ol / Heating

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; butan-1-ol;
DOI:10.1021/jm00121a022