(S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester

Base Information

• Chemical Name: (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester
• CAS No.: 872984-86-6
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.309
• Mol file: 872984-86-6.mol

Synonyms:(S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester

Chemical Property of (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester

There total 5 articles about (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-3-methyl-butyric acid methyl ester (119993-19-0,50899-66-6) → (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester (872984-86-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -40 ℃; for 23h;

DOI:10.1021/jo051890+

Reference yield:

L-Valine methyl ester (4070-48-8) + 4-methoxy-benzaldehyde (123-11-5) → (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester (872984-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / methanol / 24 h / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C

With magnesium sulfate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1021/ol303566k

Reference yield:

L-valine methylester hydrochloride (6306-52-1) → (S)-2-[3-(4-Methoxy-phenyl)-oxaziridin-2-yl]-3-methyl-butyric acid methyl ester (872984-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Na₂CO₃ / methanol / 12 h / Ambient temperature

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 14 h / Ambient temperature

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;

DOI:10.1055/s-1987-28189

upstream raw materials:

(S)-2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-3-methyl-butyric acid methyl ester

Methyl 2--3-methylbutanoate

L-valine methylester hydrochloride

4-methoxy-benzaldehyde

Downstream raw materials:

N-(2-Boc-amino-3-phenylpropyliden)-L-valin-N-oxid-methylester

(S)-methyl 2-(hydroxyamino)-3-methylbutanoate

4-methoxybenzaldehyde O-benzyloxime

O-benzyl oxime of 4-methoxybenzaldehyde