7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

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Chemical Name:7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester
CAS No.:474303-58-7
Molecular Formula:C₃₀H₃₃FN₆O₂
Molecular Weight:528.629
Hs Code.:

7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-<i>a</i>]pyridine-6-carboxylic acid ethyl ester

Synonyms:7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

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Chemical Property of 7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

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Technology Process of 7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

There total 8 articles about 7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 474304-05-7
N-cyclopentyl-3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-6-(triethoxymethyl)pyrazolo[1,5-a]pyridin-7-amine

: 474303-58-7
7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

Guidance literature:: With toluene-4-sulfonic acid; In water; acetone; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 372122-55-9
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine

: 474303-58-7
7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 94 percent / phosphorus oxychloride / 72 h / 20 °C

2.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

3.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

4.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

5.1: sodium / 20 °C

5.2: 92 percent / ethanol / 18 h / 60 °C

6.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

6.2: 46 percent / carbon tetrachloride / tetrahydrofuran; hexane / 2 h / 20 °C

7.1: 96 percent / 16 h / 80 °C

8.1: 88 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 3 h / 20 °C

With manganese(IV) oxide; n-butyllithium; sodium ethanolate; sodium; toluene-4-sulfonic acid; diisopropylamine; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; chloroform; water; acetone; 1.1: Vilsmeier-Haack formylation / 2.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015

Reference yield:

: 468062-76-2
2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carbaldehyde

: 474303-58-7
7-cyclopentylamino-3-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-pyrazolo[1,5-a]pyridine-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 96 percent / tetrahydrofuran / 14 h / 20 °C

2.1: 69 percent / manganese dioxide / CHCl₃ / 1.5 h / 0 °C

3.1: 98 percent / sodium ethoxide / ethanol / 15.5 h / 0 - 20 °C

4.1: sodium / 20 °C

4.2: 92 percent / ethanol / 18 h / 60 °C

5.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

5.2: 46 percent / carbon tetrachloride / tetrahydrofuran; hexane / 2 h / 20 °C

6.1: 96 percent / 16 h / 80 °C

7.1: 88 percent / p-toluenesulfonic acid monohydrate / acetone; H₂O / 3 h / 20 °C

With manganese(IV) oxide; n-butyllithium; sodium ethanolate; sodium; toluene-4-sulfonic acid; diisopropylamine; In tetrahydrofuran; ethanol; hexane; chloroform; water; acetone; 1.1: Grignard reaction;
DOI:10.1016/j.bmc.2005.09.015