4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

Base Information

Chemical Name:4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid
CAS No.:1233518-09-6
Molecular Formula:C₃₀H₃₂N₂O₆
Molecular Weight:516.594
Hs Code.:

Synonyms:4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

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Chemical Property of 4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

Chemical Property:

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Technology Process of 4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

There total 3 articles about 4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1353684-66-8
4-(3-(tert-butoxycarbonylamino)propylamino)benzoic acid

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1233518-09-6
4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

Guidance literature:: With sodium hydrogencarbonate; In chloroform; for 2h; Reflux;
DOI:10.1039/c001164a

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1233518-09-6
4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; triethylamine / dimethyl sulfoxide; dichloromethane / -78 - 20 °C

2: 2-picoline borane complex / methanol / 14 h / 20 °C / Inert atmosphere

3: chloroform; tetrahydrofuran / Reflux

With oxalyl dichloride; 2-picoline borane complex; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide; 1: |Swern Oxidation;
DOI:10.1016/j.bmc.2012.09.053

Reference yield:

: 58885-60-2
N-(tert-butoxycarbonyl)-3-aminopropanal

: 150-13-0,159246-81-8,8014-65-1
4-amino-benzoic acid

: 1233518-09-6
4-((((9H-fluoren-9-yl)methoxy)carbonyl)(3-(tert-butoxycarbonylamino)propyl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2-picoline borane complex / methanol / 14 h / 20 °C / Inert atmosphere

2: chloroform; tetrahydrofuran / Reflux

With 2-picoline borane complex; In tetrahydrofuran; methanol; chloroform;
DOI:10.1016/j.bmc.2012.09.053