7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

Base Information

Chemical Name:7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane
CAS No.:107098-19-1
Molecular Formula:C₄₈H₇₀N₆O₁₂S₄
Molecular Weight:1051.38
Hs Code.:

Synonyms:7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

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Chemical Property of 7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

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Technology Process of 7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

There total 5 articles about 7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 64844-66-2
4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

: 540-51-2
2-bromoethanol

: 107098-19-1
7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

Guidance literature:: With potassium carbonate; In tetrahydrofuran; for 62h; Heating;
DOI:10.1021/jo00385a003

Reference yield:

: 77429-98-2
3-benzoyl-N¹,N⁵-ditosyl-3-azapentane-1,5-diamine

: 107098-19-1
7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / cesium carbonate / dimethylformamide / 72 h / 95 °C

2: 56 percent / water, potassium tert-butoxide / tetrahydrofuran / 10 h / Heating

3: 77 percent / K₂CO₃ / tetrahydrofuran / 62 h / Heating

With potassium tert-butylate; water; potassium carbonate; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a003

Reference yield:

: 107098-11-3
9-benzoyl-6,12-bis(p-tolylsulfonyl)-6,9,12-triaza-3,15-dioxaheptadecane-1,17-diol

: 107098-19-1
7,19-bis(2-hydroxyethyl)-4,10,16,22-tetrakis(p-tolylsulfonyl)1,13-dioxa-4,7,10,16,19,22-hexaazacyclotetracosane

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

2: 53 percent / cesium carbonate / dimethylformamide / 72 h / 95 °C

3: 56 percent / water, potassium tert-butoxide / tetrahydrofuran / 10 h / Heating

4: 77 percent / K₂CO₃ / tetrahydrofuran / 62 h / Heating

With potassium tert-butylate; water; potassium carbonate; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00385a003