N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

Base Information

Chemical Name:N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide
CAS No.:1256381-57-3
Molecular Formula:C₁₆H₂₄Cl₂N₂O₂
Molecular Weight:347.285
Hs Code.:

Synonyms:N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

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Technology Process of N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

There total 1 articles about N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 305-03-3
chlorambucil

: 1256381-57-3
N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 1.08333h;
DOI:10.1021/jm101024j

Reference yield: 70.0%

: 1256381-57-3
N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

: 64977-05-5
4-(4-(N,N-bis(2-chloroethyl)amino)phenyl)butanal

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/jm101024j

Reference yield:

: 1256381-57-3
N-methyl-N-methoxy 4-(4-(N,N-bis(2-chloroethyl)amino)phenyl) butanamide

: 1256381-59-5
N-methoxy-4-(4-N',N'-bis(2-chloroethyl)amino)phenylbutylamine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

2: triethylamine / ethanol / 0.58 h

3: hydrogenchloride; triethylamine-borane / ethanol / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; triethylamine-borane; triethylamine; In tetrahydrofuran; ethanol;