3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

Base Information

Chemical Name:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide
CAS No.:921629-90-5
Molecular Formula:C₃₆H₄₇Cl₂N₃O₈S
Molecular Weight:752.756
Hs Code.:

3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

Synonyms:3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

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Chemical Property of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

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Technology Process of 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

There total 9 articles about 3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1056555-32-8
tert-butyl (3-(cyclopropyl((2-(3-methoxypropyl)-6-(3-(methylsulfonyl)propoxy)-1-oxidopyridin-4-yl)methyl)amino)-2-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzyl)-3-oxopropyl)carbamate

: 921629-90-5
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 921630-64-0
2-(2,6-dichloro-4-methyl-phenoxy)-ethanol

: 921629-90-5
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran; toluene / 4 h / 80 °C

2.1: piperidine / toluene / 3 h / Heating / reflux

3.1: sodium tetrahydroborate; cobalt(II) chloride / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C

5.1: methanol; sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

5.2: pH ~ 1

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: Oxone / tetrahydrofuran; methanol; water / 2 h / 2 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

With piperidine; hydrogenchloride; methanol; dmap; Oxone; sodium hydroxide; sodium tetrahydroborate; tributylphosphine; water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; cobalt(II) chloride; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 921630-61-7
4-[2-(2,6-dichloro-4-methyl-phenoxy)-ethoxy]-benzaldehyde

: 921629-90-5
3-amino-N-cyclopropyl-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-N-({2-(3-methoxypropyl)-6-[3-(methylsulfonyl)propoxy]-1-oxidopyridin-4-yl}methyl)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: piperidine / toluene / 3 h / Heating / reflux

2.1: sodium tetrahydroborate; cobalt(II) chloride / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / 20 °C

4.1: methanol; sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C

4.2: pH ~ 1

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

6.1: Oxone / tetrahydrofuran; methanol; water / 2 h / 2 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 20 °C

8.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

With piperidine; hydrogenchloride; methanol; dmap; Oxone; sodium hydroxide; sodium tetrahydroborate; water; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; cobalt(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;