(4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

Base Information

Chemical Name:(4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine
CAS No.:1254981-32-2
Molecular Formula:C₁₇H₁₈F₄N₄
Molecular Weight:354.35
Hs Code.:

Synonyms:(4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

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Chemical Property of (4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

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Technology Process of (4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

There total 2 articles about (4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1254981-31-1
2'-chloro-4-fluoro-4-phenyl-3'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl

: 1254981-32-2
(4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; at 160 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 1186194-98-8
2,4-dichloro-3-(trifluoromethyl)pyridine

: 1254981-32-2
(4-fluoro-4-phenyl-3′-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-2′-yl)hydrazine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h / 110 °C / Sealed tube

2: hydrazine hydrate / tetrahydrofuran / 0.75 h / 160 °C / Microwave irradiation

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm3010724