Technology Process of rac-4-allyl-3,6-dimethylcyclohex-2-enone
There total 3 articles about rac-4-allyl-3,6-dimethylcyclohex-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
rac-4-allyl-3-methylcyclohex-2-enone;
With
lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; hexane;
at -78 - 23 ℃;
Inert atmosphere;
DOI:10.3762/bjoc.7.114
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 4 h / -78 - 20 °C / Inert atmosphere
1.3: 1.5 h / -78 - 20 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -43 °C / Inert atmosphere
2.2: -43 - 20 °C / Inert atmosphere
With
n-butyllithium; diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
DOI:10.1002/anie.201403939
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: diethyl ether; hexane / -78 - 23 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: -78 - 23 °C / Inert atmosphere
With
lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.3762/bjoc.7.114
