2-Thiophenemethanol, a-(trifluoromethyl)-

Base Information

• Chemical Name: 2-Thiophenemethanol, a-(trifluoromethyl)-
• CAS No.: 35304-68-8
• Molecular Formula: C₆H₅F₃OS
• Molecular Weight: 182.166
• Mol file: 35304-68-8.mol

Synonyms:(?à)-2,2,2-Trifluoro-1-(thiophen-2-yl)ethanol;a-(Trifluoromethyl)-2-thiophenemethanol

Chemical Property of 2-Thiophenemethanol, a-(trifluoromethyl)-

Chemical Property:

• Vapor Pressure: 0.06mmHg at 25°C
• Boiling Point: 221.9±40.0 °C(Predicted)
• PKA: 11.18±0.20(Predicted)
• PSA: 48.47000
• Density: 1.441±0.06 g/cm3(Predicted)
• LogP: 2.34380
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2,2,2-Trifluoro-1-(thiophen-2-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenemethanol, a-(trifluoromethyl)-

There total 9 articles about 2-Thiophenemethanol, a-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

thiophene-2-carbaldehyde (98-03-3) + (trifluoromethyl)trimethylsilane (81290-20-2) → 2-(2,2,2-trifluoro-1-hydroxyethyl)thiophene (35304-68-8)

Guidance literature:

thiophene-2-carbaldehyde; (trifluoromethyl)trimethylsilane; With cesium fluoride; In 1,2-dimethoxyethane; at 0 - 25 ℃;

With hydrogenchloride; In 1,2-dimethoxyethane; water; for 0.5h;

Reference yield: 68.0%

thiophene-2-carbaldehyde (98-03-3) + iodotrifluoromethane (2314-97-8,263005-66-9) → 2-(2,2,2-trifluoro-1-hydroxyethyl)thiophene (35304-68-8)

Guidance literature:

With Tetrakis(dimethylamino)ethylen; In N,N-dimethyl-formamide; at -20 - 20 ℃; for 8.16667h; Irradiation;

DOI:10.1021/ol016933x

Reference yield: 65.0%

thiophene-2-carbaldehyde (98-03-3) + trifluoromethan (75-46-7) → 2-(2,2,2-trifluoro-1-hydroxyethyl)thiophene (35304-68-8)

Guidance literature:

With phosphazene base-P₄-tert-butyl; In tetrahydrofuran; hexane; at -30 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c3ob27368g

upstream raw materials:

thiophene

ethyl trifluoroacetaldehyde hemiacetal

thiophene-2-carbaldehyde

iodotrifluoromethane

Downstream raw materials:

(Z)-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)thiophene

(E)-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)thiophene

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