4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

Base Information

Chemical Name:4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine
CAS No.:160905-66-8
Molecular Formula:C₄₀H₅₇FN₄O₈Si₂
Molecular Weight:797.084
Hs Code.:

Synonyms:4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

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Chemical Property of 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

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Technology Process of 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

There total 7 articles about 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 115012-52-7
1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine

: 69304-43-4
1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N⁴-benzoylcytosine

: 160905-66-8
4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

Guidance literature:: With mesitylene sulfonic acid; In tetrahydrofuran; acetonitrile;

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 160905-66-8
4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 84.4 percent / pyridine / Ambient temperature

2: 1.) pyridine / 1) room temperature, 30 min; 2) 90 min, room temperature

3: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

4: 74.5 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

With pyridine; mesitylene sulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 98-88-4
benzoyl chloride

: 160905-66-8
4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) pyridine / 1) room temperature, 30 min; 2) 90 min, room temperature

2: toluene-p-sulfonic acid monohydrate / CH₂Cl₂; dioxane / 0.03 h

3: 74.5 percent / mesitylenesulfonic acid dihydrate / tetrahydrofuran; acetonitrile

With pyridine; mesitylene sulfonic acid; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;