2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

Base Information

Chemical Name:2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol
CAS No.:1582756-31-7
Molecular Formula:C₁₆H₁₅F₃N₆O
Molecular Weight:364.33
Hs Code.:

Synonyms:2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

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Chemical Property of 2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

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Technology Process of 2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

There total 5 articles about 2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1582753-88-5
N-(3-ethynyl-5-methylphenyl)-4-(trifluoromethyl)pyrimidin-2-amine

: 540-51-2
2-bromoethanol

: 1582756-31-7
2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

Guidance literature:: With sodium azide; copper; copper(II) sulfate; In water; tert-butyl alcohol; at 125 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

Reference yield:

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1582756-31-7
2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / Reflux

2: tris-(o-tolyl)phosphine; diisopropylamine; palladium diacetate / acetonitrile / 3 h / 75 °C / Inert atmosphere

3: potassium carbonate; methanol / 3 h

4: copper(II) sulfate; copper; sodium azide / water; tert-butyl alcohol / 0.17 h / 125 °C / Sealed tube; Microwave irradiation

With methanol; sodium azide; methanesulfonic acid; palladium diacetate; copper; potassium carbonate; copper(II) sulfate; diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 74586-53-1
3-bromo-5-methylaniline

: 1582756-31-7
2-(4-(3-methyl-5-((4-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)-1H-1,2,3-triazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonic acid / 1,4-dioxane / Reflux

2: tris-(o-tolyl)phosphine; diisopropylamine; palladium diacetate / acetonitrile / 3 h / 75 °C / Inert atmosphere

3: potassium carbonate; methanol / 3 h

4: copper(II) sulfate; copper; sodium azide / water; tert-butyl alcohol / 0.17 h / 125 °C / Sealed tube; Microwave irradiation

With methanol; sodium azide; methanesulfonic acid; palladium diacetate; copper; potassium carbonate; copper(II) sulfate; diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; water; acetonitrile; tert-butyl alcohol;