5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid

Base Information

• Chemical Name: 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid
• CAS No.: 159770-30-6
• Molecular Formula: C₁₄H₁₄N₂O₅
• Molecular Weight: 290.276
• Mol file: 159770-30-6.mol

Synonyms:5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid

Chemical Property of 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid

There total 5 articles about 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylate (159770-29-3) → 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid (159770-30-6)

Guidance literature:

With sodium hydroxide; In water; for 4h; Heating;

Reference yield:

ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate (67706-69-8) → 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid (159770-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 2 h / Heating

2: Et₃N, POCl₃ / CHCl₃ / 15 h / Ambient temperature

3: 73 percent / NaOH, H₂O / 4 h / Heating

With sodium hydroxide; water; triethylamine; trichlorophosphate; In chloroform; toluene;

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylic acid (159770-30-6)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 12 h / Ambient temperature

2: 1.) propan-2-ylmagnesium bromide / 1.) THF, r.t., 0.5 h; r.t. to 40 deg C, 0.5 h, 2.) THF, r.t., 4 h

3: toluene / 2 h / Heating

4: Et₃N, POCl₃ / CHCl₃ / 15 h / Ambient temperature

5: 73 percent / NaOH, H₂O / 4 h / Heating

With sodium hydroxide; water; isopropylmagnesium bromide; triethylamine; trichlorophosphate; In tetrahydrofuran; chloroform; toluene;

upstream raw materials:

ethyl 5-benzyloxycarbonylaminomethyl-3-methylisoxazole-4-carboxylate

ethyl 4-Benzyloxycarbonylamino-3-oxobutanoate

N-(Benzyloxycarbonyl)glycine

N-Benzyloxycarbonylglycine imidazolide

Downstream raw materials:

3-acetyltetramic acid

3-Acetyltetramic acid

C₁₇H₁₈N₂O₇