2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

Base Information

Chemical Name:2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide
CAS No.:1430072-52-8
Molecular Formula:C₂₁H₃₀N₂O₅SSi
Molecular Weight:450.631
Hs Code.:

Synonyms:2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

Chemical Property:

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Technology Process of 2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

There total 5 articles about 2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1430072-48-2
2-(4-(benzyloxy)phenylsulfonamido)acetic acid

: 41879-39-4
O-(tert-butyldimethylsilanyl)hydroxylamine

: 1430072-52-8
2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2012.12.058

Reference yield:

: 100-39-0
benzyl bromide

: 1430072-52-8
2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / isopropyl alcohol / 70 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 48.2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / water; 1,4-dioxane / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With oxalyl dichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2012.12.058

Reference yield:

: 87001-32-9
p-benzyloxybenzenesulfonyl chloride

: 1430072-52-8
2-(4-(benzyloxy)phenylsulfonamido)-N-(tert-butyldimethy-lsilyloxy)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / water; 1,4-dioxane / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.ejmech.2012.12.058