4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid
CAS No.:356566-58-0
Molecular Formula:C12H10 F2 N2 O3
Molecular Weight:268.22
Hs Code.:
DSSTox Substance ID:DTXSID40592818
Mol file:356566-58-0.mol

Synonyms:356566-58-0;4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid;4-(3,4-difluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid;4-(3,4-DIFLUOROPHENYL)-1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-5-PYRIMIDINECARBOXYLIC;4-(3,4-Difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid;A6226;SCHEMBL2570938;DTXSID40592818;BYHLVBRHNYDQMW-UHFFFAOYSA-N;DB-069245;4-(3,4-Difluoro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid;4-(3,4-Difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylicacid

Suppliers and Price of 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

Chemical Property:

PSA：81.92000
LogP:1.64610
XLogP3:0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:268.06594851
Heavy Atom Count:19
Complexity:439

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)F)C(=O)O

Technology Process of 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid

There total 2 articles about 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 34036-07-2
3,4 difluorobenzaldehyde

: 57-13-6
urea

: 356566-58-0
4-methyl-1,2,3,6-tetrahydro-2-oxo-6-(3,4-difluorophenyl)-pyrimidine-5-carboxylic acid

Guidance literature:: 4-methyleneoxetan-2-one; With dmap; polystyrene Wang resin; In 1,4-dioxane; at 20 ℃; for 18h;

3,4 difluorobenzaldehyde; urea; With hydrogenchloride; In 1,4-dioxane; at 70 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;