(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Base Information

Chemical Name:(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate
CAS No.:797759-35-4
Molecular Formula:C₁₇H₂₀FN₃O₄S
Molecular Weight:381.428
Hs Code.:

Synonyms:(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Suppliers and Price of (R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

There total 9 articles about (R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 797759-33-2
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinyl]methylamine

: 463-71-8
thiophosgene

: 797759-35-4
(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: tert-butyl (2-fluoro-4-nitrophenyl)(methyl)carbamate

: 797759-35-4
(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

2.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

3.2: 14 h / -70 - 20 °C

4.1: triethylamine / dichloromethane / 6 h / 20 °C

5.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

7.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; acetone;

Reference yield:

: tert-butyl (4-amino-2-fluorophenyl)(methyl)carbamate

: 797759-35-4
(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

2.2: 14 h / -70 - 20 °C

3.1: triethylamine / dichloromethane / 6 h / 20 °C

4.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; acetone;