(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

Base Information

Chemical Name:(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea
CAS No.:797759-38-7
Molecular Formula:C₁₈H₂₅FN₄O₄S
Molecular Weight:412.485
Hs Code.:

Synonyms:(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

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Chemical Property of (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

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Technology Process of (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

There total 10 articles about (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.44%

: 797759-35-4
(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

: 593-51-1
methylamine hydrochloride

: 797759-38-7
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

: tert-butyl (4-amino-2-fluorophenyl)(methyl)carbamate

: 797759-38-7
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

2.2: 14 h / -70 - 20 °C

3.1: triethylamine / dichloromethane / 6 h / 20 °C

4.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

7.1: triethylamine / tetrahydrofuran / 6 h / 20 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; acetone;

Reference yield:

: (R)-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinyl]methanol

: 797759-38-7
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]-N'-methylthiourea

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 6 h / 20 °C

2: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

4: triethylamine / dichloromethane / 3 h / 0 - 20 °C

5: triethylamine / tetrahydrofuran / 6 h / 20 °C

With sodium azide; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); dichloromethane;