(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Base Information

Chemical Name:(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate
CAS No.:797759-37-6
Molecular Formula:C₁₈H₂₄FN₃O₅S
Molecular Weight:413.47
Hs Code.:

Synonyms:(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Suppliers and Price of (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

There total 10 articles about (S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 67-56-1
methanol

: 797759-35-4
(R)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]isothiocyanate

: 797759-37-6
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Guidance literature:: at 80 - 100 ℃;

Reference yield:

: tert-butyl (4-amino-2-fluorophenyl)(methyl)carbamate

: 797759-37-6
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

2.2: 14 h / -70 - 20 °C

3.1: triethylamine / dichloromethane / 6 h / 20 °C

4.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

6.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

7.1: 80 - 100 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; acetone;

Reference yield:

: tert-butyl (2-fluoro-4-nitrophenyl)(methyl)carbamate

: 797759-37-6
(S)-N-[3-[3-fluoro-4-(N-t-butoxycarbonyl)methylaminophenyl]-2-oxo-5-oxazolidinylmethyl]thiocarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

2.1: sodium hydrogencarbonate / water; acetone / 14 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

3.2: 14 h / -70 - 20 °C

4.1: triethylamine / dichloromethane / 6 h / 20 °C

5.1: sodium azide / DMF (N,N-dimethyl-formamide) / 6 h / 20 - 80 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2585.81 Torr

7.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

8.1: 80 - 100 °C

With n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; water; acetone;