6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Base Information

Chemical Name:6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid
CAS No.:60750-37-0
Molecular Formula:C12H12 N2 O3
Molecular Weight:232.239
Hs Code.:2933599090
DSSTox Substance ID:DTXSID00393722
Nikkaji Number:J869.877E
Mol file:60750-37-0.mol

Synonyms:60750-37-0;6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid;6-methyl-2-oxo-4-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid;2-Oxo-4-phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid;SCHEMBL13789190;DTXSID00393722;RJPIEFIYDRBNFF-UHFFFAOYSA-N;1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-phenyl-5-pyrimidinecarboxylicacid;5-Pyrimidinecarboxylicacid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenyl-;AKOS023448116;A8456;FT-0763711;1,2,3,4-Tetrahydro-6-methyl-2-oxo-4-phenyl-5-pyrimidinecarboxylic?acid;5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenyl-;6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylicacid;6-METHYL-2-OXO-4-PHENYL-1,2,3,4-TETRAHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID

Suppliers and Price of 6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-4-PHENYL-5-PYRIMIDINECARBOXYLIC ACID 95.00%
5MG
$ 496.38

Total 5 raw suppliers

Chemical Property of 6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

Chemical Property:

Melting Point:210 °C(Solv: ethanol (64-17-5))
Boiling Point:405.9±45.0 °C(Predicted)
PKA:6.73±0.40(Predicted)
PSA：81.92000
Density:1.285±0.06 g/cm3(Predicted)
LogP:1.36790
XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:232.08479225
Heavy Atom Count:17
Complexity:370

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-4-PHENYL-5-PYRIMIDINECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(NC(=O)N1)C2=CC=CC=C2)C(=O)O

Technology Process of 6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

There total 9 articles about 6-Methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 60750-23-4
benzyl 6-methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 60750-37-0
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 40 - 45 ℃; atmospheric pressure;
DOI:10.1016/j.tet.2005.12.061

Reference yield: 89.0%

: 541-50-4
2-acetoacetic acid

: 100-52-7
benzaldehyde

: 57-13-6
urea

: 60750-37-0
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

Guidance literature:: With silicon-supported ionic liquid catalyst; In ethanol; at 20 - 30 ℃; for 0.333333h;

Reference yield: 81.0%

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 100-52-7
benzaldehyde

: 57-13-6
urea

: 60750-37-0
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid

Guidance literature:: 4-methyleneoxetan-2-one; With dmap; polystyrene Wang resin; In dichloromethane; at 20 ℃; for 18h;

benzaldehyde; urea; With hydrogenchloride; In 1,4-dioxane; at 70 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;