methyl 5--2-thiophenecarboxylate

Base Information

Chemical Name:methyl 5--2-thiophenecarboxylate
CAS No.:133380-49-1
Molecular Formula:C₁₅H₁₃NO₄S
Molecular Weight:303.339
Hs Code.:

methyl 5-<N-benzoyl-(α-aminoacetyl)>-2-thiophenecarboxylate

Synonyms:methyl 5--2-thiophenecarboxylate

Suppliers and Price of methyl 5--2-thiophenecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 5--2-thiophenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 5--2-thiophenecarboxylate

There total 6 articles about methyl 5--2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 133380-47-9
methyl 5-(α-aminoacetyl)-2-thiophenecarboxylate hydrochloride

: 98-88-4
benzoyl chloride

: 133380-49-1
methyl 5--2-thiophenecarboxylate

Guidance literature:: With triethylamine; In chloroform; for 0.25h;
DOI:10.1002/jhet.5570280104

Reference yield:

: 4565-31-5
5-formyl-2-thiophencarboxylic acid

: 133380-49-1
methyl 5--2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / Na₂CO₃ / dimethylformamide / Ambient temperature

2: 73 percent / Jones reagent / acetone / 1 h / Ambient temperature

3: SOCl₂ / 1.5 h / Heating

4: 2) HBr(g) / 1) ether, 0 deg C, overnight, 2) 20 min

5: 1) hexamethylenetetramine, 2) conc. HCl / 1) CHCl₃, RT, overnight, 2) MeOH, RT, overnight

6: 91 percent / NEt₃ / CHCl₃ / 0.25 h

With hydrogenchloride; thionyl chloride; jones reagent; hexamethylenetetramine; hydrogen bromide; sodium carbonate; triethylamine; In chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1002/jhet.5570280104

Reference yield:

: 4192-32-9
2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone

: 133380-49-1
methyl 5--2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1) hexamethylenetetramine, 2) conc. HCl / 1) CHCl₃, RT, overnight, 2) MeOH, RT, overnight

2: 91 percent / NEt₃ / CHCl₃ / 0.25 h

With hydrogenchloride; hexamethylenetetramine; triethylamine; In chloroform;
DOI:10.1002/jhet.5570280104